Serum Cytokeratin 18-Asp396 as an Early Predictor of Acute Paracetamol Hepatotoxicity

Serum levels of caspase-cleaved cytokeratin 18 (CK18-Asp396) predict severity of liver disease in chronic hepatitis B

BACKGROUND AND AIM Caspase-cleaved cytokeratin 18 (CK18-Asp396) is a potential clinically useful biomarker in liver disease as it is released from hepatocytes during apoptosis. In this study, we investigated serum CK18-Asp396 levels in chronic hepatitis B (CHB). PATIENTS AND METHODS Overall, 163 patients with CHB were included. Serum CK18-Asp396 levels were determined by enzyme-linked immunos...

Serum uric acid as an independent predictor of early death after acute stroke.

BACKGROUND The prognostic significance of uric acid (UA) levels in acute stroke is unclear, so the objective of this study was to determine the association between levels of serum UA (SUA) and mortality in acute stroke. METHODS AND RESULTS Consecutive patients (n=435) presenting with ischemic stroke and intracerebral hemorrhage were included in the study. The length of stay in hospital and th...

Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study.

BACKGROUND Although the King's College Hospital (KCH) selection criteria for emergency liver transplantation in paracetamol-induced acute liver failure are widely used, strategies to improve sensitivity and facilitate earlier transplantation are required. We investigated the use of arterial blood lactate measurement for the identification of transplantation candidates. METHODS In a single-cen...

Serum Cytokeratin-18 Levels for Liver Fibrosis Prediction

We have read with great interest the meta-analysis by Yang et al. (1). The reported objective was to evaluate the relation between cytokeratin-18 (CK-18) levels and hepatitis pathogenesis. Eight case-control studies were included in the meta-analysis according to the selection criteria adopted. High serum CK-18 levels were found in patients with hepatitis compared to controls. Moreover, increas...

serum cytokeratin-18 levels for liver fibrosis prediction